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A population-based
1:3 age-matched case-control study was conducted during 2006–2009 to
assess the role of high-level natural radiation (>1 mSv/year) on
congenital mental retardation and cleft lip/palate in the southwest
coastal area of Kerala. Dosimetry was carried out in the house where
parents resided during conception and the subsequent two trimesters of
pregnancy of the study subject. Conditional logistic regression did not
suggest any statistically significant association of either mental
retardation (n = 445) or cleft lip/palate (n = 116) with
high-level natural radiation. The odds of mental retardation and cleft
lip/palate among those exposed to high-level natural radiation relative
to normal levels of natural background radiation (≤1 mSv/year) were 1.26
(95% CI: 0.91–1.73) and 0.56 (95% CI: 0.31–1.02), respectively, after
controlling for gender and maternal age at birth of the study subject.
The data did not suggest any dose-related trend in the risk of either
mental retardation (P = 0.113) or cleft lip/palate (P =
0.908). Notwithstanding the use of a single dose estimate to reconstruct
past radiation exposure and the complex etiology of congenital
malformations, it may reasonably be concluded that the prevailing
high-level natural radiation in the study area does not appear to
increase the risk of either mental retardation or cleft lip/palate among
offspring of parents staying in the area.
Received: June 13, 2011; Accepted: September 16, 2011 ;Published Online: October 7, 2011
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